RapamycinFungusV1, Main, Exploration, bibRecord, 000922

Antifibrotic effect of rapamycin containing polyethylene glycol-coated alginate microcapsule in islet xenotransplantation.

Identifieur interne : 000922 ( Main/Exploration ); précédent : 000921; suivant : 000923

Antifibrotic effect of rapamycin containing polyethylene glycol-coated alginate microcapsule in islet xenotransplantation.

Auteurs : Heon-Seok Park [Corée du Sud] ; Ji-Won Kim [Corée du Sud] ; Seung-Hwan Lee [Corée du Sud] ; Hae Kyung Yang [Corée du Sud] ; Dong-Sik Ham [Corée du Sud] ; Cheng-Lin Sun [République populaire de Chine] ; Tae Ho Hong [Corée du Sud] ; Gilson Khang [Corée du Sud] ; Chung-Gyu Park [Corée du Sud] ; Kun-Ho Yoon [Corée du Sud]

Source :

Journal of tissue engineering and regenerative medicine [ 1932-7005 ] ; 2017.

RBID : pubmed:26043934

Descripteurs français

KwdFr :
- Acide glucuronique (composition chimique), Acides hexuroniques (composition chimique), Alginates (composition chimique), Animaux (MeSH), Capsules (MeSH), Cellules RAW 264.7 (MeSH), Diabète expérimental (anatomopathologie), Diabète expérimental (sang), Fibrose (MeSH), Glucose (pharmacologie), Glycémie (métabolisme), Ilots pancréatiques (anatomopathologie), Ilots pancréatiques (effets des médicaments et des substances chimiques), Insuline (métabolisme), Matériaux biocompatibles (pharmacologie), Matériaux revêtus, biocompatibles (composition chimique), Polyéthylène glycols (composition chimique), Prolifération cellulaire (effets des médicaments et des substances chimiques), Sirolimus (pharmacologie), Souris (MeSH), Souris de lignée BALB C (MeSH), Survie cellulaire (effets des médicaments et des substances chimiques), Sus scrofa (MeSH), Sécrétion d'insuline (MeSH), Transplantation hétérologue (MeSH).
MESH :
- anatomopathologie : Diabète expérimental, Ilots pancréatiques.
- composition chimique : Acide glucuronique, Acides hexuroniques, Alginates, Matériaux revêtus, biocompatibles, Polyéthylène glycols.
- effets des médicaments et des substances chimiques : Ilots pancréatiques, Prolifération cellulaire, Survie cellulaire.
- métabolisme : Glycémie, Insuline.
- pharmacologie : Glucose, Matériaux biocompatibles, Sirolimus.
- sang : Diabète expérimental.
- Animaux, Capsules, Cellules RAW 264.7, Fibrose, Souris, Souris de lignée BALB C, Sus scrofa, Sécrétion d'insuline, Transplantation hétérologue.

English descriptors

KwdEn :
- Alginates (chemistry), Animals (MeSH), Biocompatible Materials (pharmacology), Blood Glucose (metabolism), Capsules (MeSH), Cell Proliferation (drug effects), Cell Survival (drug effects), Coated Materials, Biocompatible (chemistry), Diabetes Mellitus, Experimental (blood), Diabetes Mellitus, Experimental (pathology), Fibrosis (MeSH), Glucose (pharmacology), Glucuronic Acid (chemistry), Hexuronic Acids (chemistry), Insulin (metabolism), Insulin Secretion (MeSH), Islets of Langerhans (drug effects), Islets of Langerhans (pathology), Mice (MeSH), Mice, Inbred BALB C (MeSH), Polyethylene Glycols (chemistry), RAW 264.7 Cells (MeSH), Sirolimus (pharmacology), Sus scrofa (MeSH), Transplantation, Heterologous (MeSH).
MESH :
- chemical , chemistry : Alginates, Coated Materials, Biocompatible, Glucuronic Acid, Hexuronic Acids, Polyethylene Glycols.
- chemical , metabolism : Blood Glucose, Insulin.
- chemical , pharmacology : Biocompatible Materials, Glucose, Sirolimus.
- blood : Diabetes Mellitus, Experimental.
- drug effects : Cell Proliferation, Cell Survival, Islets of Langerhans.
- pathology : Diabetes Mellitus, Experimental, Islets of Langerhans.
- Animals, Capsules, Fibrosis, Insulin Secretion, Mice, Mice, Inbred BALB C, RAW 264.7 Cells, Sus scrofa, Transplantation, Heterologous.

Abstract

Islet microencapsulation is an attractive strategy for the minimization or avoidance of life-long immunosuppression after transplantation. However, the clinical implementation of this technique is currently limited by incomplete biocompatibility. Thus, the aim of the present study was to demonstrate the improved biocompatibility of rapamycin-containing polyethylene glycol (Rapa-PEG)-coating on alginate microcapsules containing xenogeneic islets. The Rapa-PEG-coating on the alginate layer was observed using scanning electron microscopy (SEM) and the molecular cut-off weight of the microcapsules was approximately 70 kDa. The viabilities of the alginate-encapsulated and Rapa-PEG-coated alginate-encapsulated islets were lower than the viability of the naked islets just after encapsulation, but these the differences diminished over time in culture dishes. Rapa-PEG-coating on the alginate capsules effectively decreased the proliferation of macrophage cells compared to the non-coating and alginate coating of xenogeneic pancreas tissues. Glucose-stimulated insulin secretion did not significantly differ among the groups prior to transplantation. The random blood glucose levels of diabetic mice significantly improved following the transplantation of alginate-encapsulated and Rapa-PEG-coated alginate-encapsulated islets, but there were no significant differences between these two groups. However, there was a significant decrease in the number of microcapsules with fibrotic cell infiltration in the Rapa-PEG-coated alginate microcapsule group compared to the alginate microcapsule group. In conclusion, Rapa-PEG-coating might be an effective technique with which to improve the biocompatibility of microcapsules containing xenogeneic islets. Copyright © 2015 John Wiley & Sons, Ltd.

DOI: 10.1002/term.2029
PubMed: 26043934

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000C47
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Le document en format XML

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<author><name sortKey="Sun, Cheng Lin" sort="Sun, Cheng Lin" uniqKey="Sun C" first="Cheng-Lin" last="Sun">Cheng-Lin Sun</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Endocrinology and Metabolism, First Hospital of Jilin University, Changchun, Jilin</wicri:regionArea>
<wicri:noRegion>Jilin</wicri:noRegion>
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<author><name sortKey="Hong, Tae Ho" sort="Hong, Tae Ho" uniqKey="Hong T" first="Tae Ho" last="Hong">Tae Ho Hong</name>
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<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Surgery, College of Medicine, Catholic University of Korea, Seoul</wicri:regionArea>
<placeName><settlement type="city">Séoul</settlement>
<region type="capital">Région capitale de Séoul</region>
</placeName>
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<author><name sortKey="Khang, Gilson" sort="Khang, Gilson" uniqKey="Khang G" first="Gilson" last="Khang">Gilson Khang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Polymer Nano Science and Technology, Department of BIN Fusion Technology and BK-21 Polymer BIN Fusion Research Team, Chonbuk National University, Dukjin, Jeonju, Republic of Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Polymer Nano Science and Technology, Department of BIN Fusion Technology and BK-21 Polymer BIN Fusion Research Team, Chonbuk National University, Dukjin, Jeonju</wicri:regionArea>
<wicri:noRegion>Jeonju</wicri:noRegion>
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<author><name sortKey="Park, Chung Gyu" sort="Park, Chung Gyu" uniqKey="Park C" first="Chung-Gyu" last="Park">Chung-Gyu Park</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Microbiology and Immunology, Translational Xenotransplantation Research Centre, Cancer Research Institute, Biomedical Research Institute, College of Medicine, Seoul National University, Republic of Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Microbiology and Immunology, Translational Xenotransplantation Research Centre, Cancer Research Institute, Biomedical Research Institute, College of Medicine, Seoul National University</wicri:regionArea>
<placeName><settlement type="city">Séoul</settlement>
</placeName>
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<author><name sortKey="Yoon, Kun Ho" sort="Yoon, Kun Ho" uniqKey="Yoon K" first="Kun-Ho" last="Yoon">Kun-Ho Yoon</name>
<affiliation wicri:level="3"><nlm:affiliation>Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alginates (chemistry)</term>
<term>Animals (MeSH)</term>
<term>Biocompatible Materials (pharmacology)</term>
<term>Blood Glucose (metabolism)</term>
<term>Capsules (MeSH)</term>
<term>Cell Proliferation (drug effects)</term>
<term>Cell Survival (drug effects)</term>
<term>Coated Materials, Biocompatible (chemistry)</term>
<term>Diabetes Mellitus, Experimental (blood)</term>
<term>Diabetes Mellitus, Experimental (pathology)</term>
<term>Fibrosis (MeSH)</term>
<term>Glucose (pharmacology)</term>
<term>Glucuronic Acid (chemistry)</term>
<term>Hexuronic Acids (chemistry)</term>
<term>Insulin (metabolism)</term>
<term>Insulin Secretion (MeSH)</term>
<term>Islets of Langerhans (drug effects)</term>
<term>Islets of Langerhans (pathology)</term>
<term>Mice (MeSH)</term>
<term>Mice, Inbred BALB C (MeSH)</term>
<term>Polyethylene Glycols (chemistry)</term>
<term>RAW 264.7 Cells (MeSH)</term>
<term>Sirolimus (pharmacology)</term>
<term>Sus scrofa (MeSH)</term>
<term>Transplantation, Heterologous (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Acide glucuronique (composition chimique)</term>
<term>Acides hexuroniques (composition chimique)</term>
<term>Alginates (composition chimique)</term>
<term>Animaux (MeSH)</term>
<term>Capsules (MeSH)</term>
<term>Cellules RAW 264.7 (MeSH)</term>
<term>Diabète expérimental (anatomopathologie)</term>
<term>Diabète expérimental (sang)</term>
<term>Fibrose (MeSH)</term>
<term>Glucose (pharmacologie)</term>
<term>Glycémie (métabolisme)</term>
<term>Ilots pancréatiques (anatomopathologie)</term>
<term>Ilots pancréatiques (effets des médicaments et des substances chimiques)</term>
<term>Insuline (métabolisme)</term>
<term>Matériaux biocompatibles (pharmacologie)</term>
<term>Matériaux revêtus, biocompatibles (composition chimique)</term>
<term>Polyéthylène glycols (composition chimique)</term>
<term>Prolifération cellulaire (effets des médicaments et des substances chimiques)</term>
<term>Sirolimus (pharmacologie)</term>
<term>Souris (MeSH)</term>
<term>Souris de lignée BALB C (MeSH)</term>
<term>Survie cellulaire (effets des médicaments et des substances chimiques)</term>
<term>Sus scrofa (MeSH)</term>
<term>Sécrétion d'insuline (MeSH)</term>
<term>Transplantation hétérologue (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Alginates</term>
<term>Coated Materials, Biocompatible</term>
<term>Glucuronic Acid</term>
<term>Hexuronic Acids</term>
<term>Polyethylene Glycols</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Blood Glucose</term>
<term>Insulin</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Biocompatible Materials</term>
<term>Glucose</term>
<term>Sirolimus</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Diabète expérimental</term>
<term>Ilots pancréatiques</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Diabetes Mellitus, Experimental</term>
</keywords>
<keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Acide glucuronique</term>
<term>Acides hexuroniques</term>
<term>Alginates</term>
<term>Matériaux revêtus, biocompatibles</term>
<term>Polyéthylène glycols</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Proliferation</term>
<term>Cell Survival</term>
<term>Islets of Langerhans</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Ilots pancréatiques</term>
<term>Prolifération cellulaire</term>
<term>Survie cellulaire</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Glycémie</term>
<term>Insuline</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Diabetes Mellitus, Experimental</term>
<term>Islets of Langerhans</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Glucose</term>
<term>Matériaux biocompatibles</term>
<term>Sirolimus</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Diabète expérimental</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Capsules</term>
<term>Fibrosis</term>
<term>Insulin Secretion</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>RAW 264.7 Cells</term>
<term>Sus scrofa</term>
<term>Transplantation, Heterologous</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Capsules</term>
<term>Cellules RAW 264.7</term>
<term>Fibrose</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Sus scrofa</term>
<term>Sécrétion d'insuline</term>
<term>Transplantation hétérologue</term>
</keywords>
</textClass>
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<front><div type="abstract" xml:lang="en">Islet microencapsulation is an attractive strategy for the minimization or avoidance of life-long immunosuppression after transplantation. However, the clinical implementation of this technique is currently limited by incomplete biocompatibility. Thus, the aim of the present study was to demonstrate the improved biocompatibility of rapamycin-containing polyethylene glycol (Rapa-PEG)-coating on alginate microcapsules containing xenogeneic islets. The Rapa-PEG-coating on the alginate layer was observed using scanning electron microscopy (SEM) and the molecular cut-off weight of the microcapsules was approximately 70 kDa. The viabilities of the alginate-encapsulated and Rapa-PEG-coated alginate-encapsulated islets were lower than the viability of the naked islets just after encapsulation, but these the differences diminished over time in culture dishes. Rapa-PEG-coating on the alginate capsules effectively decreased the proliferation of macrophage cells compared to the non-coating and alginate coating of xenogeneic pancreas tissues. Glucose-stimulated insulin secretion did not significantly differ among the groups prior to transplantation. The random blood glucose levels of diabetic mice significantly improved following the transplantation of alginate-encapsulated and Rapa-PEG-coated alginate-encapsulated islets, but there were no significant differences between these two groups. However, there was a significant decrease in the number of microcapsules with fibrotic cell infiltration in the Rapa-PEG-coated alginate microcapsule group compared to the alginate microcapsule group. In conclusion, Rapa-PEG-coating might be an effective technique with which to improve the biocompatibility of microcapsules containing xenogeneic islets. Copyright © 2015 John Wiley & Sons, Ltd.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26043934</PMID>
<DateCompleted><Year>2017</Year>
<Month>11</Month>
<Day>28</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>12</Month>
<Day>17</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1932-7005</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>11</Volume>
<Issue>4</Issue>
<PubDate><Year>2017</Year>
<Month>04</Month>
</PubDate>
</JournalIssue>
<Title>Journal of tissue engineering and regenerative medicine</Title>
<ISOAbbreviation>J Tissue Eng Regen Med</ISOAbbreviation>
</Journal>
<ArticleTitle>Antifibrotic effect of rapamycin containing polyethylene glycol-coated alginate microcapsule in islet xenotransplantation.</ArticleTitle>
<Pagination><MedlinePgn>1274-1284</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1002/term.2029</ELocationID>
<Abstract><AbstractText>Islet microencapsulation is an attractive strategy for the minimization or avoidance of life-long immunosuppression after transplantation. However, the clinical implementation of this technique is currently limited by incomplete biocompatibility. Thus, the aim of the present study was to demonstrate the improved biocompatibility of rapamycin-containing polyethylene glycol (Rapa-PEG)-coating on alginate microcapsules containing xenogeneic islets. The Rapa-PEG-coating on the alginate layer was observed using scanning electron microscopy (SEM) and the molecular cut-off weight of the microcapsules was approximately 70 kDa. The viabilities of the alginate-encapsulated and Rapa-PEG-coated alginate-encapsulated islets were lower than the viability of the naked islets just after encapsulation, but these the differences diminished over time in culture dishes. Rapa-PEG-coating on the alginate capsules effectively decreased the proliferation of macrophage cells compared to the non-coating and alginate coating of xenogeneic pancreas tissues. Glucose-stimulated insulin secretion did not significantly differ among the groups prior to transplantation. The random blood glucose levels of diabetic mice significantly improved following the transplantation of alginate-encapsulated and Rapa-PEG-coated alginate-encapsulated islets, but there were no significant differences between these two groups. However, there was a significant decrease in the number of microcapsules with fibrotic cell infiltration in the Rapa-PEG-coated alginate microcapsule group compared to the alginate microcapsule group. In conclusion, Rapa-PEG-coating might be an effective technique with which to improve the biocompatibility of microcapsules containing xenogeneic islets. Copyright © 2015 John Wiley & Sons, Ltd.</AbstractText>
<CopyrightInformation>Copyright © 2015 John Wiley & Sons, Ltd.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Park</LastName>
<ForeName>Heon-Seok</ForeName>
<Initials>HS</Initials>
<AffiliationInfo><Affiliation>Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kim</LastName>
<ForeName>Ji-Won</ForeName>
<Initials>JW</Initials>
<AffiliationInfo><Affiliation>Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Convergent Research Consortium for Immunologic Disease, Seoul St Mary's Hospital, Catholic University of Korea, Seoul, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lee</LastName>
<ForeName>Seung-Hwan</ForeName>
<Initials>SH</Initials>
<AffiliationInfo><Affiliation>Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yang</LastName>
<ForeName>Hae Kyung</ForeName>
<Initials>HK</Initials>
<AffiliationInfo><Affiliation>Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ham</LastName>
<ForeName>Dong-Sik</ForeName>
<Initials>DS</Initials>
<AffiliationInfo><Affiliation>Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sun</LastName>
<ForeName>Cheng-Lin</ForeName>
<Initials>CL</Initials>
<AffiliationInfo><Affiliation>Department of Endocrinology and Metabolism, First Hospital of Jilin University, Changchun, Jilin, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hong</LastName>
<ForeName>Tae Ho</ForeName>
<Initials>TH</Initials>
<AffiliationInfo><Affiliation>Department of Surgery, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Khang</LastName>
<ForeName>Gilson</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Department of Polymer Nano Science and Technology, Department of BIN Fusion Technology and BK-21 Polymer BIN Fusion Research Team, Chonbuk National University, Dukjin, Jeonju, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Park</LastName>
<ForeName>Chung-Gyu</ForeName>
<Initials>CG</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology and Immunology, Translational Xenotransplantation Research Centre, Cancer Research Institute, Biomedical Research Institute, College of Medicine, Seoul National University, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yoon</LastName>
<ForeName>Kun-Ho</ForeName>
<Initials>KH</Initials>
<AffiliationInfo><Affiliation>Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Convergent Research Consortium for Immunologic Disease, Seoul St Mary's Hospital, Catholic University of Korea, Seoul, Republic of Korea.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2015</Year>
<Month>06</Month>
<Day>05</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>J Tissue Eng Regen Med</MedlineTA>
<NlmUniqueID>101308490</NlmUniqueID>
<ISSNLinking>1932-6254</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000464">Alginates</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D001672">Biocompatible Materials</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D001786">Blood Glucose</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D002214">Capsules</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D020099">Coated Materials, Biocompatible</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D006603">Hexuronic Acids</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
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<Chemical><RegistryNumber>3WJQ0SDW1A</RegistryNumber>
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</Chemical>
<Chemical><RegistryNumber>8A5D83Q4RW</RegistryNumber>
<NameOfSubstance UI="D020723">Glucuronic Acid</NameOfSubstance>
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</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000464" MajorTopicYN="N">Alginates</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001672" MajorTopicYN="N">Biocompatible Materials</DescriptorName>
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<MeshHeading><DescriptorName UI="D001786" MajorTopicYN="N">Blood Glucose</DescriptorName>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D002214" MajorTopicYN="N">Capsules</DescriptorName>
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<MeshHeading><DescriptorName UI="D049109" MajorTopicYN="N">Cell Proliferation</DescriptorName>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D002470" MajorTopicYN="N">Cell Survival</DescriptorName>
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<MeshHeading><DescriptorName UI="D020099" MajorTopicYN="N">Coated Materials, Biocompatible</DescriptorName>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D003921" MajorTopicYN="N">Diabetes Mellitus, Experimental</DescriptorName>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D005355" MajorTopicYN="N">Fibrosis</DescriptorName>
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<MeshHeading><DescriptorName UI="D005947" MajorTopicYN="N">Glucose</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020723" MajorTopicYN="N">Glucuronic Acid</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006603" MajorTopicYN="N">Hexuronic Acids</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007328" MajorTopicYN="N">Insulin</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000078790" MajorTopicYN="N">Insulin Secretion</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007515" MajorTopicYN="N">Islets of Langerhans</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008807" MajorTopicYN="N">Mice, Inbred BALB C</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011092" MajorTopicYN="N">Polyethylene Glycols</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000067996" MajorTopicYN="N">RAW 264.7 Cells</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020123" MajorTopicYN="N">Sirolimus</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D034421" MajorTopicYN="N">Sus scrofa</DescriptorName>
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<MeshHeading><DescriptorName UI="D014183" MajorTopicYN="Y">Transplantation, Heterologous</DescriptorName>
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<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">biocompatibility</Keyword>
<Keyword MajorTopicYN="Y">diabetes mellitus</Keyword>
<Keyword MajorTopicYN="Y">fibrosis infiltration</Keyword>
<Keyword MajorTopicYN="Y">islet transplantation</Keyword>
<Keyword MajorTopicYN="Y">microcapsule</Keyword>
<Keyword MajorTopicYN="Y">rapamycin</Keyword>
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</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year>
<Month>07</Month>
<Day>29</Day>
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<PubMedPubDate PubStatus="revised"><Year>2015</Year>
<Month>02</Month>
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<affiliations><list><country><li>Corée du Sud</li>
<li>République populaire de Chine</li>
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<settlement><li>Séoul</li>
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<orgName><li>Université nationale de Séoul</li>
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<tree><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Park, Heon Seok" sort="Park, Heon Seok" uniqKey="Park H" first="Heon-Seok" last="Park">Heon-Seok Park</name>
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<name sortKey="Kim, Ji Won" sort="Kim, Ji Won" uniqKey="Kim J" first="Ji-Won" last="Kim">Ji-Won Kim</name>
<name sortKey="Kim, Ji Won" sort="Kim, Ji Won" uniqKey="Kim J" first="Ji-Won" last="Kim">Ji-Won Kim</name>
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<name sortKey="Park, Chung Gyu" sort="Park, Chung Gyu" uniqKey="Park C" first="Chung-Gyu" last="Park">Chung-Gyu Park</name>
<name sortKey="Yang, Hae Kyung" sort="Yang, Hae Kyung" uniqKey="Yang H" first="Hae Kyung" last="Yang">Hae Kyung Yang</name>
<name sortKey="Yoon, Kun Ho" sort="Yoon, Kun Ho" uniqKey="Yoon K" first="Kun-Ho" last="Yoon">Kun-Ho Yoon</name>
<name sortKey="Yoon, Kun Ho" sort="Yoon, Kun Ho" uniqKey="Yoon K" first="Kun-Ho" last="Yoon">Kun-Ho Yoon</name>
</country>
<country name="République populaire de Chine"><noRegion><name sortKey="Sun, Cheng Lin" sort="Sun, Cheng Lin" uniqKey="Sun C" first="Cheng-Lin" last="Sun">Cheng-Lin Sun</name>
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	Serveur d'exploration sur la rapamycine et les champignons
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Antifibrotic effect of rapamycin containing polyethylene glycol-coated alginate microcapsule in islet xenotransplantation.

Antifibrotic effect of rapamycin containing polyethylene glycol-coated alginate microcapsule in islet xenotransplantation.

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